Properly designing your Trial from a methodological perspective is key to find out if and how innovative solutions can help resolving your needs. Before adopting potentially innovative solutions and investing time and money to figure out what fits you best, you may want to assess them in non operational contexts (such as a Trial) through a structured approach.

For this purpose, the DRIVER+ project has developed a specific methodology called Trial Guidance Methodology (TGM). The TGM consists of phases (Preparation, Execution, Evaluation) and steps (six-step in the preparation phase) explained in the TGM Handbook.

The TGM Handbook is now available online at